BOB.1 (ABT-BOB1) mouse mAb

产品详情

产品名称

BOB.1 (ABT-BOB1) mouse mAb

产品货号

YM-A05886

规格

50μL;100μL

种属反应

Human,Mouse,

实验应用

IHC,ELISA

分子量

35kD

宿主

Mouse

同种型

IgG2a,Kappa

修饰

Unmodified

推荐稀释比

IHC 1:50-200;ELISA 1:500-5000

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

ABT-BOB1

免疫原

Synthesized peptide derived from human BOB.1 AA range: 150-256

特异性

The antibody can specifically recognize human BOB.1 protein.

基因名称

POU2AF1 OBF1

蛋白名称

POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)

别名

基因ID-1

5450

SwissProt

Q16633

背景

disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.,function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific.,

细胞定位

Nuclear, Cytoplasmic