MUC5AC (ABT302) mouse mAb

产品详情

产品名称

MUC5AC (ABT302) mouse mAb

产品货号

YM-A05889

规格

50μL;100μL

种属反应

Human,

实验应用

IHC,IF,ELISA

分子量

宿主

Mouse

同种型

IgG2a,Kappa

修饰

Unmodified

推荐稀释比

IHC 1:200-400;IF 1:50-200;ELISA 1:500-5000

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

ABT302

免疫原

Synthesized peptide derived from human MUC5AC AA range: 2700-2900

特异性

The antibody can specifically recognize MUC5AC protein.

基因名称

MUC5AC MUC5

蛋白名称

Mucin-5AC (MUC-5AC) (Gastric mucin) (Lewis B blood group antigen) (LeB) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) (Fragments)

别名

Mucin-5AC;Gastric mucin;Major airway glycoprotein;Mucin-5 subtype AC, tracheobronchial;Tracheobronchial mucin;MUC5;MUC5AC

基因ID-1

SwissProt

P98088

背景

domain:The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.,function:Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particules that are subsequently removed by the mucocilary system.,PTM:C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.,PTM:Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 2 VWFC domains.,similarity:Contains 4 VWFD domains.,subunit:Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).,tissue specificity:Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.,

细胞定位

Cytoplasmic