Claudin 18.1 (PT0108) mouse mAb

产品详情

产品名称

Claudin 18.1 (PT0108) mouse mAb

产品货号

YM-A05916

规格

50μL;100μL

种属反应

Human,Mouse,Rat,

实验应用

IHC,IF,ELISA

分子量

宿主

Mouse

同种型

IgG1,Lambda

修饰

Unmodified

推荐稀释比

IHC 1:200-400;IF 1:50-200;ELISA 1:500-5000

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

PT0108

免疫原

Synthesized peptide derived from human Claudin 18 AA range: 1-100

特异性

This antibody detects endogenous levels of Claudin 18.1 protein.

基因名称

CLDN18 UNQ778/PRO1572

蛋白名称

Claudin 18

别名

Claudin 18 antibody;Claudin-18 antibody;CLD18_HUMAN antibody;CLDN18 antibody;SFTA5 antibody;SFTPJ antibody;

基因ID-1

51208

SwissProt

P56856

背景

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]

细胞定位

Membranous