S100 (ABT-S100B) mouse mAb

产品详情

产品名称

S100 (ABT-S100B) mouse mAb

产品货号

YM-A05971

规格

50μL;100μL

种属反应

Human,Mouse,Rat,

实验应用

IHC,IF,ELISA

分子量

宿主

Mouse

同种型

IgG1,Kappa

修饰

Unmodified

推荐稀释比

IHC 1:200-400;IF 1:50-200;ELISA 1:500-5000

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

ABT-S100B

免疫原

Synthesized peptide derived from human S100 AA range: 1-50

特异性

This antibody detects endogenous levels of S100 protein.

基因名称

S100B

蛋白名称

S100

别名

基因ID-1

6285

SwissProt

P04271

背景

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy

细胞定位

Nuclear, Cytoplasmic