Her-2 (ABT077) mouse mAb

产品详情

产品名称

Her-2 (ABT077) mouse mAb

产品货号

YM-A06024

规格

50μL;100μL

种属反应

Human,

实验应用

IHC,ELISA

分子量

180kD

宿主

Mouse

同种型

IgG2a,Kappa

修饰

Unmodified

推荐稀释比

IHC 1:200-400;ELISA 1:500-5000

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

ABT077

免疫原

Synthesized peptide derived from human Her-2 AA range: 300-400

特异性

The antibody can specifically recognize human Her-2 protein.

基因名称

ERBB2 HER2 MLN19 NEU NGL

蛋白名称

Her-2

别名

Receptor tyrosine-protein kinase erbB-2;Metastatic lymph node gene 19 protein;MLN 19;Proto-oncogene Neu;Proto-oncogene c-ErbB-2;Tyrosine kinase-type cell surface receptor HER2;p185erbB2;CD antigen CD340;

基因ID-1

2064

SwissProt

P04626

背景

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d

细胞定位

Membranous