Topoisomerase IIα (ABT272) mouse mAb

产品详情

产品名称

Topoisomerase IIα (ABT272) mouse mAb

产品货号

YM-A06046

规格

50μL;100μL

种属反应

Human,Mouse,Rat,

实验应用

IHC,ELISA

分子量

174kD

宿主

Mouse

同种型

IgG1,Kappa

修饰

Unmodified

推荐稀释比

IHC 1:200-400;ELISA 1:500-5000

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

ABT272

免疫原

Synthesized peptide derived from human Topoisomerase IIα AA range: 1400-1531

特异性

The antibody can specifically recognize human Topoisomerase IIα protein.

基因名称

TOP2A TOP2

蛋白名称

Topoisomerase IIα

别名

DNA topoisomerase 2-alpha;DNA topoisomerase II, alpha isozyme;

基因ID-1

7153

SwissProt

P11388

背景

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also pla

细胞定位

Nuclear