TCL1 (ABT378) mouse mAb

产品详情

产品名称

TCL1 (ABT378) mouse mAb

产品货号

YM-A06057

规格

50μL;100μL

种属反应

Human,

实验应用

IHC,ELISA

分子量

13kD

宿主

Mouse

同种型

IgG2b,Kappa

修饰

Unmodified

推荐稀释比

IHC 1:200-400;ELISA 1:500-5000

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

ABT378

免疫原

Synthesized peptide derived from human TCL1 AA range: 50-114

特异性

The antibody can specifically recognize human TCL1 protein.

基因名称

TCL1A TCL1

蛋白名称

TCL1

别名

T-cell leukemia/lymphoma protein 1A;Oncogene TCL-1;Oncogene TCL1;Protein p14 TCL1;

基因ID-1

8115

SwissProt

P56279

背景

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010],

细胞定位

Cytoplasmic, Nuclear