CDK6 rabbit (PT0069R) mAb

产品详情

产品名称

CDK6 rabbit (PT0069R) mAb

产品货号

YM-A06089

规格

50μL;100μL

种属反应

Human,

实验应用

WB,IHC,IF,IP,ELISA

分子量

37kD

宿主

Rabbit

同种型

IgG,Kappa

修饰

Unmodified

推荐稀释比

IHC 1:200-1000;WB 1:1000-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein A

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

PT0069R

免疫原

特异性

Endogenous

基因名称

CDK6 CDKN6

蛋白名称

Cyclin-dependent kinase 6 (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)

别名

Cyclin-dependent kinase 6;Cell division protein kinase 6;Serine/threonine-protein kinase PLSTIRE;

基因ID-1

1021

SwissProt

Q00534

背景

cyclin dependent kinase 6(CDK6) Homo sapiens The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefS

细胞定位

Nuclear