Smad2 (PT0111R) PT® Rabbit mAb

产品详情

产品名称

Smad2 (PT0111R) PT® Rabbit mAb

产品货号

YM-A06114

规格

50μL;100μL

种属反应

Human,Mouse,Rat,

实验应用

WB,IF,IP,ELISA

分子量

58kD

宿主

Rabbit

同种型

IgG,Kappa

修饰

Unmodified

推荐稀释比

WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200,

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein A

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

PT0111R

免疫原

特异性

Endogenous

基因名称

SMAD2

蛋白名称

Mothers against decapentaplegic homolog 2

别名

SMAD2;MADH2;MADR2;Mothers against decapentaplegic homolog 2;MAD homolog 2;Mothers against DPP homolog 2;JV18-1;Mad-related protein 2;hMAD-2;SMAD family member 2;SMAD 2;Smad2;hSMAD2

基因ID-1

4087

SwissProt

Q15796

背景

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation

细胞定位

Cytoplasm,Nuclear