ATF6A (PT0177R) PT® Rabbit mAb

产品详情

产品名称

ATF6A (PT0177R) PT® Rabbit mAb

产品货号

YM-A06159

规格

50μL;100μL

种属反应

Human,Mouse,Rat,

实验应用

WB,IF,IP,ELISA

分子量

100kD

宿主

Rabbit

同种型

IgG,Kappa

修饰

Unmodified

推荐稀释比

WB 1:1000-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein A

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

PT0177R

免疫原

特异性

Endogenous

基因名称

ATF6

蛋白名称

ATF6A

别名

基因ID-1

22926

SwissProt

P18850

背景

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011],

细胞定位

Cytoplasm