IBTK Polyclonal Antibody

产品详情

产品名称

IBTK Polyclonal Antibody

产品货号

YM-A06496

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

148kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;ELISA 1:5000-20000

组成

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human protein . at AA range: 410-490

特异性

IBTK Polyclonal Antibody detects endogenous levels of protein.

基因名称

IBTK BTKI KIAA1417

蛋白名称

Inhibitor of Bruton tyrosine kinase (IBtk)

别名

基因ID-1

25998

SwissProt

Q9P2D0

背景

Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014],

细胞定位

Cytoplasm. Membrane; Peripheral membrane protein. Translocates to the plasma membrane upon IgM stimulation.; [Isoform 2]: Nucleus.