UNC5D Polyclonal Antibody

产品详情

产品名称

UNC5D Polyclonal Antibody

产品货号

YM-A07286

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

104kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;ELISA 1:5000-20000

组成

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human protein . at AA range: 160-240

特异性

UNC5D Polyclonal Antibody detects endogenous levels of protein.

基因名称

UNC5D KIAA1777 UNC5H4 UNQ6012/PRO34692

蛋白名称

Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D)

别名

基因ID-1

137970

SwissProt

Q6UXZ4

背景

function:Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,PTM:Phosphorylated on cytoplasmic tyrosine residues.,PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.,similarity:Belongs to the unc-5 family.,similarity:Contains 1 death domain.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 ZU5 domain.,similarity:Contains 2 TSP type-1 domains.,subunit:Interacts with the cytoplasmic part of DCC.,

细胞定位

Cell membrane ; Single-pass type I membrane protein .