TRIPC Polyclonal Antibody

产品详情

产品名称

TRIPC Polyclonal Antibody

产品货号

YM-A07440

规格

50μL;100μL

种属反应

Human,Rat,Mouse

实验应用

WB,ELISA

分子量

219kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;ELISA 1:5000-20000

组成

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human protein . at AA range: 950-1030

特异性

TRIPC Polyclonal Antibody detects endogenous levels of protein.

基因名称

TRIP12 KIAA0045 ULF

蛋白名称

E3 ubiquitin-protein ligase TRIP12 (E3 ubiquitin-protein ligase for Arf) (ULF) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)

别名

基因ID-1

9320

SwissProt

Q14669

背景

function:Component of PA700, an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex. Specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR). Could be E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.,miscellaneous:A cysteine residue is required for ubiquitin-thioester formation.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the UPL family. K-HECT subfamily.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 1 WWE domain.,subunit:PA700 is composed of at least 16 distinct peptides ranging from 20-112 kDa.,

细胞定位

Nucleus, nucleoplasm .