P3C2A Polyclonal Antibody

产品详情

产品名称

P3C2A Polyclonal Antibody

产品货号

YM-A08167

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

185kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;ELISA 1:5000-20000

组成

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from part region of human protein

特异性

P3C2A Polyclonal Antibody detects endogenous levels of protein.

基因名称

PIK3C2A

蛋白名称

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (Phosphoinositide 3-kinase-C2-alpha)

别名

基因ID-1

5286

SwissProt

O00443

背景

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008],

细胞定位

Cell membrane . Cytoplasmic vesicle, clathrin-coated vesicle . Nucleus . Cytoplasm . Golgi apparatus, trans-Golgi network . Inserts preferentially into membranes containing PtdIns(4,5)P2 (PubMed:17038310). Associated with RNA-containing structures (PubMed:11606566). .