KGP1 Polyclonal Antibody

产品详情

产品名称

KGP1 Polyclonal Antibody

产品货号

YM-A08204

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

73kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;ELISA 1:5000-20000

组成

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from part region of human protein

特异性

KGP1 Polyclonal Antibody detects endogenous levels of protein.

基因名称

PRKG1 PRKG1B PRKGR1A PRKGR1B

蛋白名称

cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (cGMP-dependent protein kinase I) (cGKI)

别名

基因ID-1

5592

SwissProt

Q13976

背景

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-bindin

细胞定位

Cytoplasm . Colocalized with TRPC7 in the plasma membrane. .