FGD1 rabbit pAb

产品详情

产品名称

FGD1 rabbit pAb

产品货号

YM-A09578

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB

分子量

105kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human FGD1 AA range: 508-558

特异性

This antibody detects endogenous levels of FGD1 at Human/Mouse

基因名称

FGD1 FGDY ZFYVE3

蛋白名称

FGD1

别名

FYVE, RhoGEF and PH domain-containing protein 1;Faciogenital dysplasia 1 protein;Rho/Rac guanine nucleotide exchange factor FGD1;Rho/Rac GEF;Zinc finger FYVE domain-containing protein 3;

基因ID-1

2245

SwissProt

P98174

背景

This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16.[provided by RefSeq, Mar 2011],

细胞定位

Cytoplasm . Cell projection, lamellipodium . Cell projection, ruffle . Cytoplasm, cytoskeleton . Associated with membrane ruffles and lamellipodia. .