FGD4 rabbit pAb

产品详情

产品名称

FGD4 rabbit pAb

产品货号

YM-A09637

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB

分子量

85kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human FGD4 AA range: 291-341

特异性

This antibody detects endogenous levels of FGD4 at Human/Mouse/Rat

基因名称

FGD4 FRABP ZFYVE6

蛋白名称

FGD4

别名

FYVE, RhoGEF and PH domain-containing protein 4;Actin filament-binding protein frabin;FGD1-related F-actin-binding protein;Zinc finger FYVE domain-containing protein 6;

基因ID-1

121512

SwissProt

Q96M96

背景

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],

细胞定位

Cytoplasm, cytoskeleton . Cell projection, filopodium . Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). .