1C04 rabbit pAb

产品详情

产品名称

1C04 rabbit pAb

产品货号

YM-A10327

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB

分子量

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human 1C04 AA range: 110-160

特异性

This antibody detects endogenous levels of 1C04 at Human

基因名称

HLA-C HLAC

蛋白名称

1C04

别名

基因ID-1

SwissProt

P30504

背景

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008],

细胞定位

ane,extracellular region,endoplasmic reticulum,atus,plasma membrane,integral component of plasma membrane,cell surface,ER to port vesicle membrane,membrane,integral component of membrane,phaicle membrane,early endosome membrane,MHC class I protein complex,MHC class II protein complex,extracellular exosome,integral component of lumenal side of endoplasmic reticulum membrane,