Crystallin-αC Polyclonal Antibody

产品详情

产品名称

Crystallin-αC Polyclonal Antibody

产品货号

YM-A11798

规格

50μL;100μL

种属反应

Human

实验应用

WB

分子量

22kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1000

组成

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Polyclonal

克隆号

免疫原

Recombinant Protein of Crystallin-αC

特异性

The antibody detects endogenous Crystallin-αC protein.

基因名称

HSPB8

蛋白名称

Heat shock protein beta-8

别名

HSPB8;CRYAC;E2IG1;HSP22;PP1629;Heat shock protein beta-8;HspB8;Alpha-crystallin C chain;E2-induced gene 1 protein;Protein kinase H11;Small stress protein-like protein HSP22

基因ID-1

26353

SwissProt

Q9UJY1

背景

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm . Nucleus . Translocates to nuclear foci during heat shock.