CaVα2δ2 Polyclonal Antibody

产品详情

产品名称

CaVα2δ2 Polyclonal Antibody

产品货号

YM-A11805

规格

50μL;100μL

种属反应

Human,Rat,Mouse

实验应用

WB,IHC,IF

分子量

100-120kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthetic Peptide of CaVα2δ2 AA range: 540-620

特异性

The antibody detects endogenous CaVα2δ2 protein

基因名称

CACNA2D2

蛋白名称

Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]

别名

Voltage-dependent calcium channel subunit alpha-2/delta-2;Voltage-gated calcium channel subunit alpha-2/delta-2;[Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2;Voltage-dependent calcium channel subunit delta-2]

基因ID-1

9254

SwissProt

Q9NY47

背景

calcium voltage-gated channel auxiliary subunit alpha2delta 2(CACNA2D2) Homo sapiens Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to

细胞定位

Membrane ; Single-pass type I membrane protein . Colocalizes with CACNA1A in lipid raft fractions. .