Bestrophin-1 Polyclonal Antibody

产品详情

产品名称

Bestrophin-1 Polyclonal Antibody

产品货号

YM-A11823

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC,IF

分子量

67kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthetic Peptide of Bestrophin-1 AA range: 161-211

特异性

The antibody detects endogenous Bestrophin-1 protein

基因名称

BEST1

蛋白名称

Bestrophin-1 (TU15B) (Vitelliform macular dystrophy protein 2)

别名

Bestrophin-1;TU15B;Vitelliform macular dystrophy protein 2;

基因ID-1

7439

SwissProt

O76090

背景

This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008],

细胞定位

Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane .