AMPKα2 Polyclonal Antibody

产品详情

产品名称

AMPKα2 Polyclonal Antibody

产品货号

YM-A11838

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB

分子量

62kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:1000-2000

组成

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Polyclonal

克隆号

免疫原

Recombinant Protein of AMPKα2

特异性

The antibody detects endogenous AMPKα2 protein.

基因名称

PRKAA2

蛋白名称

5'-AMP-activated protein kinase catalytic subunit alpha-2

别名

PRKAA2;AMPK;AMPK2;5'-AMP-activated protein kinase catalytic subunit alpha-2;AMPK subunit alpha-2;Acetyl-CoA carboxylase kinase;ACACA kinase;Hydroxymethylglutaryl-CoA reductase kinase;HMGCR kinase

基因ID-1

5563

SwissProt

P54646

背景

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters. .