Caspase-8 (phospho Ser347) Polyclonal Antibody

产品详情

产品名称

Caspase-8 (phospho Ser347) Polyclonal Antibody

产品货号

YM-A14995

规格

50μL;100μL

种属反应

Human,Rat

实验应用

WB,IHC,IF,ELISA

分子量

55kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human Caspase 8 around the phosphorylation site of Ser347. AA range:313-362

特异性

Phospho-Caspase-8 (S347) Polyclonal Antibody detects endogenous levels of Caspase-8 protein only when phosphorylated at S347.

基因名称

CASP8

蛋白名称

Caspase8

别名

CASP8;MCH5;Caspase-8;CASP-8;Apoptotic cysteine protease;Apoptotic protease Mch-5;CAP4;FADD-homologous ICE/ced-3-like protease;FADD-like ICE;FLICE;ICE-like apoptotic protease 5;MORT1-associated ced-3 homolog;MACH

基因ID-1

841

SwissProt

Q14790

背景

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alt

细胞定位

Cytoplasm . Nucleus .