Vav (phospho Tyr174) Polyclonal Antibody

产品详情

产品名称

Vav (phospho Tyr174) Polyclonal Antibody

产品货号

YM-A15222

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

100kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized phospho-peptide around the phosphorylation site of human Vav (phospho Tyr174)

特异性

Phospho-Vav (Y174) Polyclonal Antibody detects endogenous levels of Vav protein only when phosphorylated at Y174.

基因名称

VAV1

蛋白名称

Proto-oncogene vav

别名

VAV1;VAV;Proto-oncogene vav

基因ID-1

7409

SwissProt

P15498

背景

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012],

细胞定位

intracellular,cytosol,plasma membrane,cell-cell junction,