Btk (phospho Tyr551) Polyclonal Antibody

产品详情

产品名称

Btk (phospho Tyr551) Polyclonal Antibody

产品货号

YM-A15237

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,ELISA

分子量

80kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human BTK around the phosphorylation site of Tyr551. AA range:516-565

特异性

Phospho-Btk (Y551) Polyclonal Antibody detects endogenous levels of Btk protein only when phosphorylated at Y551.

基因名称

BTK

蛋白名称

Tyrosine-protein kinase BTK

别名

BTK;AGMX1;ATK;BPK;Tyrosine-protein kinase BTK;Agammaglobulinaemia tyrosine kinase;ATK;B-cell progenitor kinase;BPK;Bruton tyrosine kinase

基因ID-1

695

SwissProt

Q06187

背景

The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013],

细胞定位

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1.