KOR-1 (phospho Ser369) Polyclonal Antibody

产品详情

产品名称

KOR-1 (phospho Ser369) Polyclonal Antibody

产品货号

YM-A15250

规格

50μL;100μL

种属反应

Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

42kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from mouse KOR-1 around the phosphorylation site of Ser369. AA range:331-380

特异性

Phospho-KOR-1 (S369) Polyclonal Antibody detects endogenous levels of KOR-1 protein only when phosphorylated at S369.

基因名称

OPRK1

蛋白名称

Kappa-type opioid receptor

别名

OPRK1;OPRK;Kappa-type opioid receptor;K-OR-1;KOR-1

基因ID-1

4986

SwissProt

P41145

背景

Endogenous opioid peptides and opiates, like morphine, transmit their pharmacological effects through membrane bound opioid receptors. Pharmacological studies and molecular cloning have led to the identification of three different types of opioid receptor, mu-type, delta-type and kappa-type, also designated MOR-1, DOR-1 and KOR-1, respectively. MOR-1 is a receptor for beta-endorphin, DOR-1 is a receptor for enkephalins, and KOR-1 is a receptor for dynorphins.The three opioid receptor types are highly homologous and belong to the superfamily of G-protein-coupled receptors. Opioid receptors have been shown to modulate a range of brain functions, including instinctive behavior and emotions. This regulation is thought to involve the inhibition of neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.

细胞定位