Troponin I-C (phospho Thr142) Polyclonal Antibody

产品详情

产品名称

Troponin I-C (phospho Thr142) Polyclonal Antibody

产品货号

YM-A15270

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

28kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;ELISA 1:20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human TNNI3 around the phosphorylation site of Thr142. AA range:111-160

特异性

Phospho-Troponin I-C (T142) Polyclonal Antibody detects endogenous levels of Troponin I-C protein only when phosphorylated at T142.

基因名称

TNNI3

蛋白名称

Troponin I cardiac muscle

别名

TNNI3;TNNC1;Troponin I;cardiac muscle;Cardiac troponin I

基因ID-1

7137

SwissProt

P19429

背景

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008],

细胞定位

cytosol,troponin complex,sarcomere,