LAT (phospho Tyr200) Polyclonal Antibody

产品详情

产品名称

LAT (phospho Tyr200) Polyclonal Antibody

产品货号

YM-A15276

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC

分子量

34kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-2000;IHC 1:50-300

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human LAT around the phosphorylation site of Tyr171. AA range:171-220

特异性

Phospho-LAT (Y200) Polyclonal Antibody detects endogenous levels of LAT protein only when phosphorylated at Y200.

基因名称

LAT

蛋白名称

Linker for activation of T-cells family member 1

别名

LAT;Linker for activation of T-cells family member 1;36 kDa phospho-tyrosine adapter protein;pp36;p36-38

基因ID-1

27040

SwissProt

O43561

背景

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

细胞定位

Cell membrane ; Single-pass type III membrane protein . Present in lipid rafts.