IL-10Rα (phospho Tyr496) Polyclonal Antibody

产品详情

产品名称

IL-10Rα (phospho Tyr496) Polyclonal Antibody

产品货号

YM-A15317

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB,ELISA

分子量

63kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human IL-10R alpha around the phosphorylation site of Tyr496. AA range:462-511

特异性

Phospho-IL-10Rα (Y496) Polyclonal Antibody detects endogenous levels of IL-10Rα protein only when phosphorylated at Y496.

基因名称

IL10RA

蛋白名称

Interleukin-10 receptor subunit alpha

别名

IL10RA;IL10R;Interleukin-10 receptor subunit alpha;IL-10 receptor subunit alpha;IL-10R subunit alpha;IL-10RA;CDw210a;Interleukin-10 receptor subunit 1;IL-10R subunit 1;IL-10R1;CD antigen CD210

基因ID-1

3587

SwissProt

Q13651

背景

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009],

细胞定位

Cell membrane ; Single-pass type I membrane protein. Cytoplasm .