LEF-1 (phospho Ser42) Polyclonal Antibody

产品详情

产品名称

LEF-1 (phospho Ser42) Polyclonal Antibody

产品货号

YM-A15323

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC

分子量

55kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-2000;IHC 1:50-300

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human LEF-1 around the phosphorylation site of Ser42. AA range:8-57

特异性

Phospho-LEF-1 (S42) Polyclonal Antibody detects endogenous levels of LEF-1 protein only when phosphorylated at S42.

基因名称

LEF1

蛋白名称

Lymphoid enhancer-binding factor 1

别名

LEF1;Lymphoid enhancer-binding factor 1;LEF-1;T cell-specific transcription factor 1-alpha;TCF1-alpha

基因ID-1

51176

SwissProt

Q9UJU2

背景

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],

细胞定位

Nucleus . Found in nuclear bodies upon PIASG binding. .