MRE11 (phospho Ser264) Polyclonal Antibody

产品详情

产品名称

MRE11 (phospho Ser264) Polyclonal Antibody

产品货号

YM-A15343

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,ELISA,IHC

分子量

80kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human MRE11 around the phosphorylation site of Ser264. AA range:230-279

特异性

Phospho-MRE11 (S264) Polyclonal Antibody detects endogenous levels of MRE11 protein only when phosphorylated at S264.

基因名称

MRE11A

蛋白名称

Double-strand break repair protein MRE11A

别名

MRE11A;HNGS1;MRE11;Double-strand break repair protein MRE11A;Meiotic recombination 11 homolog 1;MRE11 homolog 1;Meiotic recombination 11 homolog A;MRE11 homolog A

基因ID-1

4361

SwissProt

P49959

背景

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

细胞定位

Nucleus . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents. .