Flt-3 (phospho Tyr842) Polyclonal Antibody

产品详情

产品名称

Flt-3 (phospho Tyr842) Polyclonal Antibody

产品货号

YM-A15369

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

170kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human FLT3 around the phosphorylation site of Tyr842. AA range:808-857

特异性

Phospho-Flt-3 (Y842) Polyclonal Antibody detects endogenous levels of Flt-3 protein only when phosphorylated at Y842.

基因名称

FLT3

蛋白名称

Receptor-type tyrosine-protein kinase FLT3

别名

FLT3;CD135;FLK2;STK1;Receptor-type tyrosine-protein kinase FLT3;FL cytokine receptor;Fetal liver kinase-2;FLK-2;Fms-like tyrosine kinase 3;FLT-3;Stem cell tyrosine kinase 1;STK-1;CD antigen CD135

基因ID-1

2322

SwissProt

P36888

背景

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015],

细胞定位

Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.