c-Fos (phospho Ser32) Polyclonal Antibody

产品详情

产品名称

c-Fos (phospho Ser32) Polyclonal Antibody

产品货号

YM-A15391

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,ELISA

分子量

62kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;ELISA 1:5000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human FOS around the phosphorylation site of Ser32. AA range:15-64

特异性

Phospho-c-Fos (S32) Polyclonal Antibody detects endogenous levels of c-Fos protein only when phosphorylated at S32.

基因名称

FOS

蛋白名称

Proto-oncogene c-Fos

别名

FOS;G0S7;Proto-oncogene c-Fos;Cellular oncogene fos;G0/G1 switch regulatory protein 7

基因ID-1

2353

SwissProt

P01100

背景

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008],

细胞定位

Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.