PAK5/6 (phospho Ser602/S560) Polyclonal Antibody

产品详情

产品名称

PAK5/6 (phospho Ser602/S560) Polyclonal Antibody

产品货号

YM-A15424

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

75kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human PAK5/6 around the phosphorylation site of Ser602/Ser560. AA range:566-615

特异性

Phospho-PAK5/6 (S602/S560) Polyclonal Antibody detects endogenous levels of PAK5/6 protein only when phosphorylated at S602/S560.

基因名称

PAK6/PAK7

蛋白名称

Serine/threonine-protein kinase PAK 6/7

别名

PAK7;KIAA1264;PAK5;Serine/threonine-protein kinase PAK 7;p21-activated kinase 5;PAK-5;p21-activated kinase 7;PAK-7;PAK6;PAK5;Serine/threonine-protein kinase PAK 6;PAK-5;p21-activated kinase 6;PAK-6

基因ID-1

57144;56924

SwissProt

Q9P286;Q9NQU5

背景

The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],

细胞定位

Mitochondrion. Cytoplasm. Nucleus. Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.