PR (phospho Ser400) Polyclonal Antibody

产品详情

产品名称

PR (phospho Ser400) Polyclonal Antibody

产品货号

YM-A15480

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB,IHC

分子量

99kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-2000;IHC 1:50-300

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human Progesterone Receptor around the phosphorylation site of Ser400. AA range:371-420

特异性

Phospho-PR (S400) Polyclonal Antibody detects endogenous levels of PR protein only when phosphorylated at S400.

基因名称

PGR

蛋白名称

Progesterone receptor

别名

PGR;NR3C3;Progesterone receptor;PR;Nuclear receptor subfamily 3 group C member 3

基因ID-1

5241

SwissProt

P06401

背景

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015],

细胞定位

Nucleus. Cytoplasm. Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.; [Isoform A]: Nucleus. Cytoplasm. Mainly nuclear.; [Isoform 4]: Mitochondrion outer membrane .