AMPKα1/2 (phospho Thr183/172) Polyclonal Antibody

产品详情

产品名称

AMPKα1/2 (phospho Thr183/172) Polyclonal Antibody

产品货号

YM-A15523

规格

50μL;100μL

种属反应

Human,Mouse,Rat,Monkey,Pig,Marsupenaeus japonicus

实验应用

IF,WB,IHC,ELISA

分子量

63kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

IF 1:50-200;WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;Not yet tested in other applications;

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

特异性

Phospho-AMPKα1/2 (T183/172) Polyclonal Antibody detects endogenous levels of AMPKα1/2 protein only when phosphorylated at T183/172.

基因名称

AAPK1/AAPK2

蛋白名称

5'-AMP-activated protein kinase catalytic subunit alpha-1/2

别名

PRKAA1;AMPK1;5'-AMP-activated protein kinase catalytic subunit alpha-1;AMPK subunit alpha-1;Acetyl-CoA carboxylase kinase;ACACA kinase;Hydroxymethylglutaryl-CoA reductase kinase;HMGCR kinase;Tau-protein kinase PRKAA1;PRKAA2;AMPK;

基因ID-1

5562;5563

SwissProt

Q13131;P54646

背景

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters. .