SH-PTP1 (phospho Tyr536) Polyclonal Antibody

产品详情

产品名称

SH-PTP1 (phospho Tyr536) Polyclonal Antibody

产品货号

YM-A15528

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

67kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human SHP-1 around the phosphorylation site of Tyr536. AA range:502-551

特异性

Phospho-SH-PTP1 (Y536) Polyclonal Antibody detects endogenous levels of SH-PTP1 protein only when phosphorylated at Y536.

基因名称

PTPN6

蛋白名称

Tyrosine-protein phosphatase non-receptor type 6

别名

PTPN6;HCP;PTP1C;Tyrosine-protein phosphatase non-receptor type 6;Hematopoietic cell protein-tyrosine phosphatase;Protein-tyrosine phosphatase 1C;PTP-1C;Protein-tyrosine phosphatase SHP-1;SH-PTP1

基因ID-1

5777

SwissProt

P29350

背景

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul

细胞定位

Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. .