PDE4B/C/D (phospho Ser133/119/190) Polyclonal Antibody

产品详情

产品名称

PDE4B/C/D (phospho Ser133/119/190) Polyclonal Antibody

产品货号

YM-A15616

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

76kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human PDE4D around the phosphorylation site of Ser190/53. AA range:156-205

特异性

Phospho-PDE4B/C/D (S133/119/190) Polyclonal Antibody detects endogenous levels of PDE4B/C/D protein only when phosphorylated at S133/119/190.

基因名称

PDE4B/PDE4C/PDE4D

蛋白名称

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

别名

PDE4B;DPDE4;cAMP-specific 3';5'-cyclic phosphodiesterase 4B;DPDE4;PDE32;PDE4C;DPDE1;cAMP-specific 3',5'-cyclic phosphodiesterase 4C;DPDE1;PDE21;PDE4D;DPDE3;cAMP-specific 3',5'-cyclic phosphodiesterase 4D;DPDE3;PDE43

基因ID-1

5144

SwissProt

Q07343;Q08493;Q08499

背景

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],

细胞定位

[Isoform PDE4B5]: Cytoplasm . Cell membrane .