XIAP (phospho Ser87) Polyclonal Antibody

产品详情

产品名称

XIAP (phospho Ser87) Polyclonal Antibody

产品货号

YM-A15629

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

57kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human XIAP around the phosphorylation site of Ser87. AA range:53-102

特异性

Phospho-XIAP (S87) Polyclonal Antibody detects endogenous levels of XIAP protein only when phosphorylated at S87.

基因名称

XIAP

蛋白名称

E3 ubiquitin-protein ligase XIAP

别名

XIAP;API3;BIRC4;IAP3;E3 ubiquitin-protein ligase XIAP;Baculoviral IAP repeat-containing protein 4;IAP-like protein;ILP;hILP;Inhibitor of apoptosis protein 3;IAP-3;hIAP-3;hIAP3;X-linked inhibitor of apoptosis protein;X-linked I

基因ID-1

331

SwissProt

P98170

背景

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011],

细胞定位

Cytoplasm. Nucleus. TLE3 promotes its nuclear localization.