MAPKAPK-2 (phospho Thr222) Polyclonal Antibody

产品详情

产品名称

MAPKAPK-2 (phospho Thr222) Polyclonal Antibody

产品货号

YM-A15640

规格

50μL;100μL

种属反应

Human,Mouse,Rat,Monkey

实验应用

WB,IHC,IF,ELISA

分子量

45kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human MAPKAPK-2 around the phosphorylation site of Thr222. AA range:188-237

特异性

Phospho-MAPKAPK-2 (T222) Polyclonal Antibody detects endogenous levels of MAPKAPK-2 protein only when phosphorylated at T222.

基因名称

MAPKAPK2

蛋白名称

MAP kinase-activated protein kinase 2

别名

MAPKAPK2;MAP kinase-activated protein kinase 2;MAPK-activated protein kinase 2;MAPKAP kinase 2;MAPKAP-K2;MAPKAPK-2;MK-2;MK2

基因ID-1

9261

SwissProt

P49137

背景

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm . Nucleus . Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm.