MEK-3 (phospho Thr222) Polyclonal Antibody

产品详情

产品名称

MEK-3 (phospho Thr222) Polyclonal Antibody

产品货号

YM-A15737

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

39kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human MAP2K3 around the phosphorylation site of Thr222. AA range:188-237

特异性

Phospho-MEK-3 (T222) Polyclonal Antibody detects endogenous levels of MEK-3 protein only when phosphorylated at T222.

基因名称

MAP2K3

蛋白名称

Dual specificity mitogen-activated protein kinase kinase 3

别名

MAP2K3;MEK3;MKK3;PRKMK3;SKK2;Dual specificity mitogen-activated protein kinase kinase 3;MAP kinase kinase 3;MAPKK 3;MAPK/ERK kinase 3;MEK 3;Stress-activated protein kinase kinase 2;SAPK kinase 2;SAPKK-2;SAPKK2

基因ID-1

5606

SwissProt

P46734

背景

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008],

细胞定位

nucleoplasm,cytoplasm,cytosol,membrane,