Trk C (phospho Tyr516) Polyclonal Antibody

产品详情

产品名称

Trk C (phospho Tyr516) Polyclonal Antibody

产品货号

YM-A15748

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

160kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human Trk C around the phosphorylation site of Tyr516. AA range:482-531

特异性

Phospho-Trk C (Y516) Polyclonal Antibody detects endogenous levels of Trk C protein only when phosphorylated at Y516.

基因名称

NTRK3

蛋白名称

NT-3 growth factor receptor

别名

NTRK3;TRKC;NT-3 growth factor receptor;GP145-TrkC;Trk-C;Neurotrophic tyrosine kinase receptor type 3;TrkC tyrosine kinase

基因ID-1

4916

SwissProt

Q16288

背景

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],

细胞定位

Membrane; Single-pass type I membrane protein.