KIR3.1 (phospho Ser185) Polyclonal Antibody

产品详情

产品名称

KIR3.1 (phospho Ser185) Polyclonal Antibody

产品货号

YM-A15879

规格

50μL;100μL

种属反应

Human,Mouse,Rat,Monkey

实验应用

WB,IHC,IF,ELISA

分子量

50kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human GIRK1/KIR3.1/KCNJ3 around the phosphorylation site of Ser185. AA range:151-200

特异性

Phospho-KIR3.1 (S185) Polyclonal Antibody detects endogenous levels of KIR3.1 protein only when phosphorylated at S185.

基因名称

KCNJ3

蛋白名称

G protein-activated inward rectifier potassium channel 1

别名

KCNJ3;GIRK1;G protein-activated inward rectifier potassium channel 1;GIRK-1;Inward rectifier K;+;channel Kir3.1;Potassium channel;inwardly rectifying subfamily J member 3

基因ID-1

3760

SwissProt

P48549

背景

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, at

细胞定位

Membrane; Multi-pass membrane protein.