PDGFR-β (phospho Tyr1021) Polyclonal Antibody

产品详情

产品名称

PDGFR-β (phospho Tyr1021) Polyclonal Antibody

产品货号

YM-A15941

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

135-180kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human PDGFR beta around the phosphorylation site of Tyr1021. AA range:991-1040

特异性

Phospho-PDGFR-β (Y1021) Polyclonal Antibody detects endogenous levels of PDGFR-β protein only when phosphorylated at Y1021.

基因名称

PDGFRB

蛋白名称

Platelet-derived growth factor receptor beta

别名

PDGFRB;PDGFR;PDGFR1;Platelet-derived growth factor receptor beta;PDGF-R-beta;PDGFR-beta;Beta platelet-derived growth factor receptor;Beta-type platelet-derived growth factor receptor;CD140 antigen-like family member B;Platelet-deri

基因ID-1

5159

SwissProt

P09619

背景

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008],

细胞定位

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.