4E-BP1 (phospho Thr70) Polyclonal Antibody

产品详情

产品名称

4E-BP1 (phospho Thr70) Polyclonal Antibody

产品货号

YM-A16022

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

IHC,IF,ELISA

分子量

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human 4E-BP1 around the phosphorylation site of Thr70. AA range:36-85

特异性

Phospho-4E-BP1 (T70) Polyclonal Antibody detects endogenous levels of 4E-BP1 protein only when phosphorylated at T70.

基因名称

EIF4EBP1

蛋白名称

Eukaryotic translation initiation factor 4E-binding protein 1

别名

EIF4EBP1;Eukaryotic translation initiation factor 4E-binding protein 1;4E-BP1;eIF4E-binding protein 1;Phosphorylated heat- and acid-stable protein regulated by insulin 1;PHAS-I

基因ID-1

1978

SwissProt

Q13541

背景

eukaryotic translation initiation factor 4E binding protein 1(EIF4EBP1) Homo sapiens This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008],

细胞定位

nucleoplasm,cytoplasm,cytosol,protein complex,