HtrA2 (phospho Ser142) Polyclonal Antibody

产品详情

产品名称

HtrA2 (phospho Ser142) Polyclonal Antibody

产品货号

YM-A16063

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

IHC,IF,ELISA

分子量

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized phospho-peptide around the phosphorylation site of human HtrA2 (phospho Ser142)

特异性

Phospho-HtrA2 (S142) Polyclonal Antibody detects endogenous levels of HtrA2 protein only when phosphorylated at S142.

基因名称

HTRA2

蛋白名称

Serine protease HTRA2 mitochondrial

别名

HTRA2;OMI;PRSS25;Serine protease HTRA2;mitochondrial;High temperature requirement protein A2;HtrA2;Omi stress-regulated endoprotease;Serine protease 25;Serine proteinase OMI

基因ID-1

27429

SwissProt

O43464

背景

This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],

细胞定位

Mitochondrion intermembrane space. Mitochondrion membrane ; Single-pass membrane protein . Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.; [Isoform 1]: Endoplasmic reticulum .