PLB (phospho Ser16/T17) Polyclonal Antibody

产品详情

产品名称

PLB (phospho Ser16/T17) Polyclonal Antibody

产品货号

YM-A16109

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC

分子量

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

WB 1:500-2000;IHC 1:50-300

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human PLB around the phosphorylation site of Ser16 and Thr17. AA range:1-50

特异性

Phospho-PLB (S16/T17) Polyclonal Antibody detects endogenous levels of PLB protein only when phosphorylated at S16/T17.

基因名称

PLN

蛋白名称

Cardiac phospholamban

别名

PLN;PLB;Cardiac phospholamban;PLB

基因ID-1

5350

SwissProt

P26678

背景

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016],

细胞定位

Endoplasmic reticulum membrane ; Single-pass membrane protein . Sarcoplasmic reticulum membrane ; Single-pass membrane protein . Mitochondrion membrane ; Single-pass membrane protein . Membrane ; Single-pass membrane protein . Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648). .