AR (phospho Ser94) Polyclonal Antibody

产品详情

产品名称

AR (phospho Ser94) Polyclonal Antibody

产品货号

YM-A16113

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

IF,ELISA

分子量

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications;

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human Androgen Receptor around the phosphorylation site of Ser94. AA range:66-115

特异性

Phospho-AR (S94) Polyclonal Antibody detects endogenous levels of AR protein only when phosphorylated at S94.

基因名称

AR

蛋白名称

Androgen receptor

别名

AR;DHTR;NR3C4;Androgen receptor;Dihydrotestosterone receptor;Nuclear receptor subfamily 3 group C member 4

基因ID-1

367

SwissProt

P10275

背景

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform

细胞定位

Nucleus . Cytoplasm . Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. .