MARK2 (phospho Thr596) Polyclonal Antibody

产品详情

产品名称

MARK2 (phospho Thr596) Polyclonal Antibody

产品货号

YM-A16134

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

IF,ELISA

分子量

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications;

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human MARK2 around the phosphorylation site of Thr596. AA range:562-611

特异性

Phospho-MARK2 (T596) Polyclonal Antibody detects endogenous levels of MARK2 protein only when phosphorylated at T596.

基因名称

MARK2

蛋白名称

Serine/threonine-protein kinase MARK2

别名

MARK2;EMK1;Serine/threonine-protein kinase MARK2;ELKL motif kinase 1;EMK-1;MAP/microtubule affinity-regulating kinase 2;PAR1 homolog;PAR1 homolog b;Par-1b;Par1b

基因ID-1

2011

SwissProt

Q7KZI7

背景

microtubule affinity regulating kinase 2(MARK2) Homo sapiens This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009],

细胞定位

Cell membrane; Peripheral membrane protein. Cytoplasm. Lateral cell membrane. Cytoplasm, cytoskeleton. Cell projection, dendrite . Cytoplasm . Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm.