EGFR (Phospho Tyr998) Polyclonal Antibody

产品详情

产品名称

EGFR (Phospho Tyr998) Polyclonal Antibody

产品货号

YM-A16181

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

IHC,IF,WB

分子量

175kD

宿主

Rabbit

同种型

IgG

修饰

Phospho

推荐稀释比

IHC 1:50-200;WB 1:500-2000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human EGFR (Phospho-Tyr998)

特异性

This antibody detects endogenous phospho levels of EGFR (Phospho-Tyr998) at Human:Y998, Mouse:Y1000, Rat:Y999

基因名称

EGFR ERBB ERBB1 HER1

蛋白名称

EGFR (Phospho-Tyr998)

别名

Epidermal growth factor receptor;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1;

基因ID-1

1956

SwissProt

P00533

背景

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016],

细胞定位

Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). .; [Isoform 2]: Secreted.